Spatial dissection of tumor immune microenvironment: basic and translational research applications

Applications for fundamental and translational research

Speaker: Daniela Quail, PhD, Assistant Professor, Rosalind and Morris Goodman Cancer Institute and the Department of Physiology, McGill University

High-parameter tools allow the study of the complexity of cancer and the heterogeneity across tumors, regardless of location and type. Quail describes the use of Imaging Mass Cytometry™ to understand immune dynamics in tumors – first in the brain tumor microenvironment to identify new cell populations that might help understand tumor biology and second in non-small cell lung cancer patients to predict recurrence and survival outcomes.
She outlines panel optimization strategies, data segmentation and functional analysis to derive clinical meaning from a minimum number of markers that create the best prediction outcomes.