Connecting Cells to Patient Outcomes

→ Speaker: Jonathan Irish, PhD, Vanderbilt University

Irish presents his latest work on glioblastoma, focusing on contrasting immune microenvironments seen in glioblastoma tumor types that can be detected on MRI. He discusses the use of CyTOF® as a great technique for quantifying and characterizing all of the cells that are present in the tissue, including key navigation, T cell subtyping, activation and memory, checkpoint and life and death markers that allow measurement of what correlates with treatment responses or prognostic signatures.

All of the work from this presentation, especially the algorithms, are available through the Cancer & Immunology Core, for researchers both in and outside of Vanderbilt. With a goal of guiding precision medicine with cytometry studies, Irish’s talk connects tumor cell biology to clinically accessible tests.