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Using Mass Cytometry to Dissect Underlying Immune Patterns across Human Disease | Dr. Helen McGuire

21 October 2020

Fluidigm Greater Asia Webinar Series with Guest Speakers from Asia Pacific regions.

Guest Speaker: Dr Helen McGuire, Senior Research Fellow - Ramaciotti Facility for Human Systems Biology, Discipline of Pathology, The University of Sydney. NSW Councillor for Australian and New Zealand Society for Immunology (ASI) and 2020/2021 President of Australasian Cytometry Society (ACS).

Mass cytometry, or Cytometry by Time-Of-Flight (CyTOF), is a powerful platform for high-dimensional single-cell analysis of the immune system. It enables the simultaneous measurement of over 40 markers on individual cells through the use of monoclonal antibodies conjugated to rare-earth heavy metal isotopes. This talk will focus on the potential of mass cytometry to unravel phenotypic and functional features of multiple immune cell populations for simultaneous assessment, tying these patterns to underlying health and disease. This presentation explores the underlying heterogeneity of immune patterns, with vignettes featuring analysis of athletes, burn survivors, and patients undergoing treatment for bone marrow transplantation and various cancers. Live discussion and Q&A following presentation.

Dr Helen McGuire is a Senior Research Fellow at the Ramaciotti Facility for Human Systems Biology, an initiative established in 2013 to support the development of mass cytometry and broader systems biology analysis across the University of Sydney campus and wider collaborative links. Her research focus and interest lies in the clinical application of immunological studies to a range of human diseases including coordinating a large cancer program, and she is particularly passionate about applying recent technological advances such as mass cytometry to facilitate comprehensive immune-profiling. Helen is an ISAC Marylou Ingram Scholar and the current President of the Australasian Cytometry Society.